Wrinkle & Radiance Remedy
Split face clinical study was conducted in July 2014 to compare a mass-market anti-aging skin care system including MD Complete Wrinkle & Radiance Remedy to a professionally dispensed prescription anti-aging skin care system that included 0.025% tretinoin (retinoid) cream. Fourteen subjects who had moderate photo damaged facial skin were enrolled and consented then alternately assigned to either right or left sides of the face with the mass market anti-aging system and the prescription anti-aging system which included 0.025% tretinoin (retinoid) cream to the other side of their face. Subjects had four visits over 12 weeks for digital photography and surveys. Blinded physicians evaluated the photographs. Physician objective analysis showed that both systems had statistically significant clinical improvement in the appearance of fine lines and wrinkles after 12 weeks of use and that there was no statistically significant difference between the two treatments. The results demonstrate that usage of MD Complete Wrinkle & Radiance Remedy results in similar clinical improvements in the appearance of fine lines and wrinkles as the leading prescription cream.
Dark Spot Corrector
Blinded, randomized, split-face clinical trial was conducted in February 2013 to compare MD Complete Dark Spot Corrector against Clinique Dark Spot Corrector which is the leading department store product for the treatment of facial hyperpigmentation and photo aging. Twenty-nine (29) participants ages 35-60 with mottled pigmentation and photo-damaged facial skin were recruited; consented and randomly assigned left/right side of face for usage of MD Complete Dark Spot Corrector (Treatment A) versus Clinique Even Better Dark Spot Corrector (Treatment B). Participants used a gentle cleanser on both sides of their face morning and evening. They applied a pearl-sized amount of each treatment (MDC Dark Spot Corrector and Clinique Even Better Dark Spot Corrector) to the designated half of their face, avoiding eyes both morning and evening. In the morning, subjects also applied an SPF 50 facial moisturizer to both sides of their face. The study was twelve weeks and conducted under the supervision of a clinical investigator. Evaluations of efficacy included two blinded physicians evaluating overall hyperpigmentation using the following grading scale: overall hyperpigmentation: 0 = none, 1 = trace, with light hyperpigmentation involving small areas, 2 = mild, with moderate hyperpigmentation involving small areas OR light hyperpigmentation involving moderate areas, 3 = moderate, with moderate hyperpigmentation involving moderate areas OR light hyperpigmentation involving all areas and 4 = severe, with marked hyperpigmentation. MD Complete average grading improved from 2.34 at baseline to 1.91 after 12 weeks. Clinique average grading improved from 2.40 at baseline to 2.14 after 12 weeks. MD Complete reduction (-0.431) was 67% greater than Clinique reduction (-0.259).